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CXCL4, CHEMOKINE
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DeCS
Descriptor
English
:
Platelet Factor 4
Descriptor
Spanish
:
Factor Plaquetario 4
Descriptor
Portuguese
:
Fator Plaquetário 4
Synonyms
English
:
Heparin Neutralizing Protein
PF4 (Platelet Factor 4)
gamma-Thromboglobulin
CXCL4, Chemokine
Chemokine, CXCL4
gamma Thromboglobulin
Antiheparin Factor
CXCL4 Chemokine
Chemokine CXCL4
Tree Number:
D12.644.276.374.200.120.900
D12.776.124.125.720
D12.776.467.374.200.120.900
D23.119.940
D23.125.300.120.900
D23.469.200.120.900
D23.529.374.200.120.900
Definition
English
:
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution.
Platelet factor 4
has a high affinity for
HEPARIN
and is often found complexed with
GLYCOPROTEINS
such as
PROTEIN C.
Pharmacological Action:
Coagulants
History Note
English
:
84(76); was see under BLOOD COAGULATION FACTORS 1976-83
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22259
Unique Identifier:
D010978
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS